Schizophrenia

noreply@blogger.com (Jon Brassey) — Mon, 30 Apr 2007 13:28:00 +0000

This review is a pragmatic attempt to highlight recent research and some backround reading in schizophrenia. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

Click here to see all the TRIP Evidence Reviews.

Evidence-Based Reports

Epilepsy or a family history of epilepsy increases the risk of schizophrenia or schizophrenia-like psychosis. Evidence-Based Mental Health (requires free registration), 2006
Schizophrenia and suicide. Bandolier, 2006 View article OR Can you answer this related question for extra CPD?
Stable monotherapy with clozapine or olanzapine increases the incidence of diabetes mellitus in people with schizophrenia. Evidence-Based Mental Health (requires free registration), 2005
Aripiprazole is effective for relapse prevention in people with chronic stable schizophrenia. Evidence-Based Mental Health (requires free registration), 2005
NHS study questions use of new schizophrenia drugs. Hitting the Headlines, 2006
Review: high doses of antipsychotic drugs are no more or less effective than medium doses in people with schizophrenia. Evidence-Based Mental Health (requires free registration), 2005
About 30% of men with schizophrenia or schizoaffective disorders have obsessive-compulsive symptoms. Evidence-Based Mental Health (requires free registration), 2006
Review: women with schizophrenia have poorer pregnancy outcomes than other women, but it is unclear whether antipsychotic medications affect their infants. Evidence-Based Mental Health (requires free registration), 2004

Clinical Guidelines

Schizophrenia. PRODIGY, 2007
Schizophrenia: core interventions in the treatment and management of schizophrenia in primary and secondary care. NICE, 2002
Consensus statement on high-dose antipsychotic medication. Royal College of Psychiatrists, 2006
Practice guideline for the treatment of patients with schizophrenia. American Psychiatric Association, 2004
Summary Australian and New Zealand Clinical Practice Guideline for the Treatment of Schizophrenia. New Zealand Guidelines Group, 2005

Systematic Reviews

Benzodiazepines for schizophrenia. Cochrane Database of Systematic Reviews. 2007 View article OR Can you answer this related question for extra CPD?
Interventions to reduce weight gain in schizophrenia. Cochrane Database of Systematic Reviews, 2007
Mother and baby units for schizophrenia. Cochrane Database of Systematic Reviews, 2007
Molindone for schizophrenia and severe mental illness. Cochrane Database of Systematic Reviews, 2007
Depot fluspirilene for schizophrenia. Cochrane Database of Systematic Reviews, 2007 View article OR Can you answer this related question for extra CPD?
Cessation of medication for people with schizophrenia already stable on chlorpromazine. Cochrane Database of Systematic Reviews, 2007
Drama therapy for schizophrenia or schizophrenia-like illnesses. Cochrane Database of Systematic Reviews, 2007

Recent articles in core journals

Paliperidone extended-release tablets for prevention of symptom recurrence in patients with schizophrenia: a randomized, double-blind, placebo-controlled study. Journal of Clinical Psychopharmacology, 2007
Randomized controlled trial of the effect on Quality of Life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Archives of General Psychiatry, 2006
Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. American Journal of Psychiatry, 2006
Childhood-onset schizophrenia: A double-blind, randomized clozapine-olanzapine comparison. Archives of General Psychiatry, 2006
Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. American Journal of Psychiatry, 2006
Long-term course of cognitive impairment in schizophrenia. British Journal of Psychiatry, 2006
Adherence therapy for people with schizophrenia. European multicentre randomised controlled trial. British Journal of Psychiatry, 2006
Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Archives of General Psychiatry, 2007

eTextbooks

eMedicine
eMedicine. Schizophrenia and Other Psychoses (pediatrics)
Merck Manual
Merck Manual (childhood)
GP Notebook

Clinical Queries

I was told by a psychiatrist that Efamarine capsules are beneficial in schizophrenia when combined with antipsychotics. Is there any research evidence for this and if so what is it? NLH Q&A Service, 2006
For a woman with a history of schizophrenia, using sodium valproate and amisulpride what contraceptive options are available? Faculty of Family Planning &amp;amp; Reproductive Health Care Q&A, 2006
Is it advised to perform routine ECGs on all schizophrenic patients prior to commencing on atypical antipsychotic medication? ATTRACT, 2005

Patient Information

TRIP Evidence Reviews: Schizophrenia

Schizophrenia